Purpose: To develop a high resolution microarray based method to detect single- and multiexons gene deletions and duplications. Methods: We have developed a high-resolution comparative genomic ...

Johns Hopkins researchers report that the deletion of any single gene in yeast cells puts pressure on the organism's genome to compensate, leading to a mutation in another gene. Their discovery, which ...

In a recent study published in the journal PLoS ONE, researchers investigated the effect of genetic variability based on accessory gene deletions on severe acute respiratory syndrome coronavirus 2 ...

Genetic mutations kick start cancers. Some mutations shuffle the genetic code, others come from the deletion of key genes. At La Jolla Institute for Immunology (LJI), researchers have made a major ...

Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes, according to new research. Neurodevelopmental ...

Loss of a small portion of chromosome 16, known as 16p11.2, is significantly associated with autism report researchers from the University of Chicago Medical Center, the University of Illinois at ...

Gene knockouts often fail to reveal phenotypes, suggesting that biological systems are laden with compensation mechanisms, which might involve functional redundancy between duplicated genes or between ...

New findings in mice suggest that the lack of a copy of the gene MVP may contribute to the symptoms of 16p11.2 deletion syndrome because it is needed for brain circuits to incorporate changes driven ...

Researchers at Rutgers and Emory University have gained new insights into how schizophrenia (SCZ) develops, by studying 3q29 deletion syndrome, which represents the strongest-known genetic risk factor ...