Aging and cancer are deeply intertwined: advancing age is the single largest risk factor for most malignancies, and many of the molecular processes that ...

Mitochondria are central hubs for cellular stress adaptation, with their function integrated with both apoptosis and autophagy pathways that determine cell fate. Alterations in mitochondrial ...

Autophagy is essentially the 'rubbish collection' of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest ...

Even under normal dietary conditions, Atg14 HepKO mice developed severe hepatomegaly, with liver weight increasing nearly fivefold. ALT and AST surged markedly, confirming hepatocellular injury.

Memorial Hospital for Cancer and Allied Diseases and the Memorial Sloan Kettering Cancer Center have disclosed 4-aminoquinoline inhibitors of the autophagy-lysosomal pathway (ALP) intended for the ...

Autophagy is a natural, conserved process where cells degrade and recycle their own components, including damaged proteins and organelles. This targeted removal is orchestrated by cargo receptors, ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A Korean research team has become the first in the world to significantly ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

Researchers in Spain have found that chaperone-mediated autophagy, a selective protein cleanup process, is markedly reduced in the motor neurons of ALS patients. The deficiency may contribute to toxic ...