Protein disulfide isomerase a4 (PDIA4) is implicated in the growth and death of tumor cells; however, its molecular mechanism and therapeutic potential in cancer are unclear. Here, we found that PDIA4 ...

Cholesterol-dependent cytolysins (CDCs) are a large family of secreted bacterial pore-forming toxins that specifically bind cholesterol-containing mammalian membranes 1. Although the pore size ...

Magnetic micropillar arrays consist of tiny, vertical pin-shaped structures, arranged in a grid-like pattern. These micropillars can change their shape to a pre-programmed geometry when exposed to a ...

A team of scientists from the University of Saskatchewan, Canada, has recently demonstrated that chemical agents capable of reducing disulfide (S-S) bonds can be potentially used as antiviral drugs ...

As global demand for green hydrogen surges, a new mini-review published in ENGINEERING Energy (formerly Frontiers in Energy) provides a definitive roadmap for using molybdenum disulfide (MoS₂) as a ...

Imagine a world where rooms are lit by their walls, clothes are smartphones and windows turn into video screens. That may seem like a bit of science fiction, but not for long. Researchers at MIT are ...

The modified lipid nanoparticle (CDL-LNP) contains several ingredients that work together to deliver mRNA effectively: the mRNA payload with genetic instructions, standard lipid molecules (ionizable ...

Cysteine’s thiol chemistry makes it central to forming disulfide bonds that lock peptides into stable, functional shapes. By combining careful placement of cysteine residues with selective protection ...

Severe acute respiratory syndrome virus 2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), uses its spike (S) glycoprotein to enter host cells. The S glycoprotein consists of ...

Iron disulfide is a cubic chemical compound with the formula FeS 2. It is usually found associated with other sulfides or oxides in metamorphic rock, sedimentary rock and quartz veins. It is dark gray ...