2020年6月27日讯/生物谷BIOON/---在一项新的研究中,来自美国桑福德-伯纳姆-普利贝斯医学发现研究所(Sanford Burnham Prebys Medical ...
本研究针对缺血性血管病变中MEK-ERK1/2和PKC通路调控ETB 受体功能异常的机制难题,通过大鼠基底动脉器官培养模型结合药理学 ...
本综述系统探讨了蛋白激酶C(PKC)抑制剂H-7在癌症治疗中的机制与应用前景。文章重点解析了H-7对PKC、PKA和PKG的多靶点抑制特性,及其通过干扰下游信号通路影响肿瘤代谢和细胞死亡的作用机制,为癌症靶向治疗提供了新的理论依据和潜在策略。 Abstract 蛋白 ...
Phorbol 12-myristate 13-acetate(PMA,佛波酯,AbMole,M4647)是一种从植物中提取的二酯类化合物,PMA的化学结构使其能够模拟细胞内重要的信号分子二酰基甘油(DAG),进而激活蛋白激酶C(PKC)。AbMole为全球科研客户提供高纯度、高生物活性的抑制剂、细胞因子、人源 ...
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in Western countries, including Brazil. 1 It comprises a group of lymphomas characterized by an aggressive clinical course, ...
In Alzheimer's disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons. Now, researchers have found that the enzyme Protein Kinase C (PKC) alpha is ...
Primary analysis of a phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma.