尽管有大量证据表明巨噬细胞能够在急性髓系白血病（AML）及其他疾病中发挥控制肿瘤的作用，但增强巨噬细胞吞噬作用的治疗药物，包括抗 CD47 中和抗体，尚未带来更好的临床效果。因此，需要更全面地了解抑制人类巨噬细胞吞噬作用的肿瘤内在因素。

Researchers have developed a modified CRISPR gene-editing tool with potential to silence the extra chromosome causing Down ...

Stay on top of what’s happening in the Bay Area with essential Bay Area news stories, sent to your inbox every weekday. The Bay Bay Area-raised host Ericka Cruz Guevarra brings you context and ...

在肉眼无法企及的微观世界里，一场残酷的进化军备竞赛每天都在真实地上演。地球上数量最庞大的生物实体——噬菌体（bacteriophages），正无休止地向细菌发起致命的感染攻击。为了在这场生死存亡的较量中幸存，细菌在漫长的岁月里进化出了高度复杂的先天 ...

Head and neck cancers often begin in the mouth, throat, or voice box. They're among the most common cancers in the world, affecting over half a million people each year and causing about 300,000 ...

Banas is associate director of research at the Gene Editing Institute at ChristianaCare, where Kmiec is founder and executive director. The medical promise of CRISPR gene editing can be seen most ...

A compact Cas12f nuclease shows high editing efficiency in human cells, with structural insights enabling an engineered variant potentially suited for future AAV‑compatible delivery.

CRISPR-Cas systems are bacterial adaptive immune systems that target and cut the nucleic acids (DNA/RNA) of invading genetic parasites like bacteriophages (phages); viruses that infect - and ...

The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA ...

At the heart of this technology is the Cas9 protein, often likened to molecular scissors, capable of cutting strands of DNA at specific locations dictated by a single guide RNA. With this mechanism, ...